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  • Professor of Medicine, University of California, San Francisco
  • San Francisco General Hospital

https://profiles.ucsf.edu/philip.j.rosenthal

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The model name Duricef is discontinued, and cefadroxil is out there in generic type. Mar 20, 2020 · CrCl 25 to 50 mL/min: 1 g orally adopted by 500 mg orally every 12 hours CrCl 10 to 25 mL/min: 1 g orally adopted by 500 mg orally each 24 hours Cefadroxil systemic 500 mg (Zenith 500 mg 4058) View all pictures. Rx only To scale back the development of drug-resistant micro organism and keep the effectiveness of cefadroxil capsules and other antibacterial medication, cefadroxil capsules should be used only to treat or stop infections which might be confirmed or strongly suspected to be brought on by bacteria. Cefadroxil monohydrate is a semisynthetic cephalosporin antibiotic intended for oral administration. In addition, each capsule additionally contains the following inactive elements: crospovidone, D&C Red No. Peak urine concentrations are approximately 1800 mcg/mL during the interval following a single 500-mg oral dose. Increases in dosage typically produce a proportionate enhance in cefadroxil monohydrate urinary concentration. Microbiology In vitro tests show that the cephalosporins are bactericidal due to their inhibition of cell-wall synthesis. It has no activity towards Pseudomonas species and Acinetobacter calcoaceticus (formerly Mima and Herellea species). Susceptibility tests: Diffusion methods The use of antibiotic disk susceptibility test methods which measure zone diameter give an accurate estimation of antibiotic susceptibility. One such commonplace procedure1 which has been really helpful for use with disks to test susceptibility of organisms to cefadroxil makes use of the cephalosporin class (cephalothin) disk. Reports from the laboratory giving results of the standard single-disk susceptibility test with a 30 mcg cephalothin disk ought to be interpreted in accordance with the next standards: Zone diameter (mm) Interpretation ≥ 18 (S) Susceptible 15-17 (I) Intermediate ≤ 14 (R) Resistant A report of "Susceptible" indicates that the pathogen is more likely to be inhibited by usually achievable blood levels. A report of "Intermediate prone" suggests that the organism can be vulnerable if excessive dosage is used or if the infection is confined to tissue and fluids (e. A report of "Resistant' indicates that achievable concentrations of the antibiotic are unlikely to be inhibitory and other remedy ought to be selected. As with normal diffusion strategies, dilution procedures require the usage of laboratory control organisms.

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Microbiology Azithromycin acts by binding to the 50S ribosomal subunit of vulnerable microorganisms and, thus, interfering with microbial protein synthesis. Using such methodology, the ratio of intracellular to extra-cellular concentration was >30 after one hour incubation. Most strains of Enterococcus faecalis and methicillin-resistant staphylococci are resistant to azithromycin. The following in vitro information can be found, however their clinical significance is unknown. Intravenous remedy must be adopted by azithromycin by the oral route at a single, day by day dose of 500 mg, administered as two 250-mg tablets to full a 7- to 10-day course of remedy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with medical response. Intravenous remedy should be followed by azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. If particulate matter is obvious in reconstituted fluids, the drug answer ought to be discarded. Previous studies have revealed colonization prevalence ranging between 20%-40%, which is reported because the prevalence restrict in literature, in different study populations (Chambers & Deleo, 2009; Sivaraman et al. Similar results have also been reported by different studies which targeted on faculty college students in Tanzania (Okamo et al. On the opposite, different published stories have indicated prevalences outdoors the 20-forty% restrict. A examine conducted on healthy volunteers in Tunisia reported a nasal colonization prevalence of 13% (Ben Slama et al. Therefore, the high prevalence of colonization observed on nasal cavities and phones might be attributed to particular features of this study’s individuals. According to obtainable literature, the presence of the mecA gene varieties the idea of resistance to beta-lactam antibiotics (Murakami et al. Therefore, basing on ideas by the majority of researchers on this field, the mecA gene was linked to cefoxitin resistance among the many mecA-positive isolates recovered in this examine. This discovering was unclear, although other research reviews demonstrated the existence of comparable observations (Chlebowicz et al.

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Aggressive supportive care is crucial in the management of colchicine poisoned sufferers. Early fluid resuscitation and correction of electrolyte abnormalities are essential. Cardiac dysrhythmias, myocardial infarction, seizures, infections, coagulopathy, rhabdomyolysis, renal failure and hypotension must be treated symptomatically in the event that they happen. Ventilator help and blood product transfusions are often wanted in the patient severely poisoned by colchicine. Patients who develop bone marrow suppression must be placed on neutropenic precautions. Discussion of case questions What initial signs, signs and historical past should raise a clinician’s index of suspicion for colchicine toxicity on this case? Persistent nausea, abdominal pain, vomiting and diarrhea in a patient with a history of arthritis should immediately direct the clinician to contemplate colchicine poisoning within the differential diagnosis. Were the indicators and signs this patient skilled according to the different phases of colchicine toxicity? Initial gastrointestinal symptoms adopted by hypotension then cardiovascular collapse and neutropenia are according to colchicine poisoning. Reconstituted vials should be neutralized with 5 meq sodium bicarbonate for every 500 mg used. Disposition of metronidazole in the physique is analogous for each oral and intravenous dosage types, with a mean elimination half-life in wholesome humans of eight hours. The major route of elimination of metronidazole and its metabolites is via the urine (60-eighty% of the dose), with fecal excretion accounting for six-15% of the dose. The metabolites that seem within the urine outcome primarily from aspect-chain oxidation [1-(ß-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole-1-yl-acetic acid] and glucuronide conjugation, with unchanged metronidazole accounting for about 20% of the total. Metronidazole is the most important part showing within the plasma, with lesser quantities of the two-hydroxymethyl metabolite additionally being current.

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Important Information Myambutol can cause critical imaginative and prescient problems or irreversible vision loss. You might not be able to take Myambutol if you have an eye fixed downside or vision dysfunction. You might not be capable of take this drugs if you have a watch condition known as optic neuritis (inflammation of nerve fibers behind your eyes). Your physician will resolve if this remedy is true for if you have an eye fixed dysfunction. Myambutol could cause vision issues that could be a sign that you need to stop taking the drugs. Young youngsters or debilitated sufferers could not have the ability to inform somebody about vision issues. Your physician might occasionally change your dose to ensure you get one of the best results. Do not take Myambutol in larger or smaller quantities or for longer than beneficial. Your blood cells, kidney operate, and liver perform may have to be checked. Myambutol unwanted effects Get emergency medical help if you have any of those indicators of an allergic reaction: hives; difficult respiratory; swelling of your face, lips, tongue, or throat. Myambutol can cause serious imaginative and prescient issues, including imaginative and prescient loss that could be permanent. Stop using this drugs and call your doctor directly if you have any issues with one or each of your eyes, corresponding to: blurred imaginative and prescient or bother focusing; loss of vision in a single eye that lasts an hour or longer; elevated sensitivity of your eyes to light; lack of colour vision; or pain with eye motion, pain behind your eyes. Call your doctor directly in case you have: new or worsening cough with fever, bother respiration; numbness of tingling in your hands or feet; confusion, hallucinations; fever, swollen glands, painful mouth sores, pores and skin sores, cold or flu symptoms, common unwell feeling; easy bruising or bleeding (nosebleeds, bleeding gums); chest ache or shortness of breath with mild exertion; little or no urinating; liver problems--higher abdomen ache, darkish urine, clay-coloured stools, jaundice (yellowing of the pores and skin or eyes); or extreme pores and skin response--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin ache, followed by a red or purple pores and skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Other medication could work together with ethambutol, including prescription and over-the-counter medicines, nutritional vitamins, and herbal products. Medical Disclaimer More about Myambutol (ethambutol) Consumer resources Professional resources Related treatment guides When a pharmaceutical company modifications any doc, a brand new model is printed on medicines. Product labeling paperwork embody info like generic names, lively components, ingredient strength dosage, routes of administration, look, utilization, warnings, inactive ingredients, etc.

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The indication for every product is for the treatment of otitis externa in dogs related to prone strains of bacteria (Staphylococcus pseudintermedius) and yeast (Malassezia pachydermatis). Florfenicol is effective for treating bacterial infections in fish, similar to trout and salmon (Fukui et al. In sea turtles the clearance was rapid (60–one hundred ml/kg/h) and the half-life was brief (Stamper et al. Mild diarrhea and elevated bilirubin have been reported from administration to horses (McKellar and Varma, 1996). When poisonous overdoses have been administered to calves (200 mg/kg) there was marked anorexia, lower in physique weight, ketosis, and elevated liver enzymes. These results included vital hematological abnormalities and protein lower. Withdrawal time for oral administration to pigs in feed is 13 days and for administration in water 16 days. Do not administer to dairy cows older than 20 months, to calves under 1 month of age, or to calves on an all-milk diet. The macrolide antibiotics are a bunch of structurally related compounds, most of that are derived from varied species of Streptomyces soil-borne bacteria. Chemically, all of the medicine in this group are categorized as macrocyclic lactones, with members containing 12–20 atoms of carbon within the lactone ring construction (Table 36. Attached to this lactone ring are various combinations of deoxy sugars held to the lactone ring by glycosidic linkages. Azithromycin is a human drug and the others are approved to be used in cattle and/or pigs. The in vitro antibacterial exercise of macrolides varies based on the pH of the tradition medium and the pH at the site of infection. Subsequently, antibacterial activity decreases in acid pH and increases in alkaline circumstances. Therefore, in an acidic environment, corresponding to in an abscess, necrotic tissue, or urine, the antibacterial activity is suppressed. The ribosomal attenuation (most common mechanism) involves methylation of the 50S drug receptor website.

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I much prefer the BioMycin which is identical energetic ingredient however with a no sting additive. May 14 2017 We are proud to declare that we will establish each certainly one of our 200 goats by name. Aug 30 2010 It is believed that the causes of pink eye in sheep and goats are totally different to that of cattle. Ladies and gents The Most Beautiful Goat in accordance with the judges of the Mazayen al Maaz competition in Riyadh. Three episodes of salmonellosis in goats had been just like the illness described in neonatal calves 2 to four week old calves and adult cattle. She was born April 15 2015 stored as a dry yearling 2016 had twins each of 2017 2020 s Mountain goats are the only living species within the genus Oreamnos. However there are two specific inherited conditions of goats that lead to contracted tendons of newborns. Most pets arrive at shelters as a result of the owner needed to move may not afford the pet had a death in the family or just gave up the responsibly of being a care taker for a Pig. Goat herders like Canaday and Gonzalez say focused grazing for fire prevention is a more environmental method than chemical brush removal and safer than controlled burns or mechanized abatement that might during occasions of drought spark an out of control fire. Apr 05 2019 A goat that doesn 39 t really feel good gained 39 t transfer around and gained 39 t eat well. The remainder of the herd A preventive measure that seems to work is using a daily footbath of zinc sulfate. Syringes Anthelmintic Cydectin Anthelmintics in South Africa Copper oxide wire partices A coccidiostat can be added to feed mineral or water. Sep 20 2020 2 Female Goats Mother and daughter Mother is the black one she is about 3 1 2 years old her daughter is the brown one and he or she is 2 1 2 years old. Have both rabbit and goats on the market moderately priced rabbits prepared now call 567 674 6600 ask for Bruce. By offering a healthier microbial stability in a number of species it helps maintain animals on feed throughout occasions of stress and aids within the digestion of nutrients for optimum feed effectivity. Goats with rapid foot progress and in an overgrown situation have been extra susceptible to foot disease than goats with slower rising toes.

Diseases

  • Amaurosis
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  • Neuritis with brachial predilection
  • Contractures of feet-muscle atrophy-oculomotor apraxia
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Increased danger of achilles tendon rupture with quinolone antibacterial use, especially in aged patients taking oral corticosteroids. The danger of fluoroquinolone-induced tendinopathy and tendon rupture: what does the clinician must know? Gatifloxacin, gemifloxacin, and moxifloxacin: The role of 3 newer fluoroquinolones. Characterization of fluoroquinolone-induced achilles tendon toxicity in rats: comparability of toxicities of 10 fluoroquinolones and results of anti-inflammatory compounds. Author Info Nazanin Foroutan* Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, IranCitation: Foroutan N (2019) Tendon Rupture as a Probable Side Effect of Ciprofloxacin: A Review Article. Mar 31 2019 Future easy Used for predictions spontaneous reactions and guarantees Future with quot going to quot Used for plans events and things you see are about to happen Future excellent Used for what will have been completed by a future moment in time Future steady Used for what shall be occurring at a selected moment in time sooner or later Present steady for the longer term Used for scheduled unit_1_lesson_4_day_2_function_families_worksheet. Formally verify 136 Unit 6 Cause Effect Essays What is a great matter for a trigger impact essay This type of essay could focus more on the causes or extra on the consequences but most writers reply this question by pondering of an effect or a last end result. After you write them down compare your studying together with your classmates academics and fogeys. What are some strategies that nurses can use to promote health literacy choose all Feb 25 2020 Unit Overview Overview of topics by lesson 1 an introduction to the categories and sources of energy 2 vitality consumption and conservation and renewable vs. This unit was developed for sixth grade social studies college students in Memphis public schools. In the Content Questions Board Game game children answer content material questions like What do seeds have to grow Word Skills Game. Choose a which means for each nook of the room and clarify it to students and then have college students go to the corner that most closely fits their opinion or reply. All Categories Anthropology Biology Business Chemistry Communication Computer Economics Education English Finance Foreign Language Geography Geology Health History Human Services Math Medical Philosophy Professional Psychology Activity 5 short solutions 10 mins Place all the image cards Worksheets 1 and three on the desk in three groups these related to I m not these associated to have haven t and people associated to don twork stay. As a multi tradition exercise give students a chance to talk about how The Food Pyramid recommendations are different than those of their native country. Play the rest of the interview Claire s answer from 00 11secs and ask college students to reply the 2 questions.

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In one embodiment, a minimum of 80% of the dosage kind will dissolve in the first half-hour. In one embodiment, a minimum of eighty% of the dosage form will dissolve within the first quarter-hour. The phrase “elimination half life” or “T1/2,” as used herein, has the standard that means utilized in pharmacokinetics, i. The term “glycerol formal,” as used herein means an organic solvent of formula C4H8O3 that exists as a mix of 5-hydroxy-1,3-dioxane and four-hydroxymethyl-1,three-dioxolane in a ratio of about 60:forty. This is as a result of the 5-hydroxy-1,three-dioxane and four-hydroxymethyl-1,3-dioxolane are in equilibrium with one another. In one embodiment, the dose of roxithromycin is administered to a mammal by injection. In one embodiment, the dose of roxithromycin is run to a cat by injection. In one embodiment, the dose of roxithromycin is run to a dog by injection. In one embodiment, the dose of roxithromycin is administered to cattle by injection. In one embodiment, the dose of roxithromycin is administered by subcutaneous injection. In one embodiment, the dose of roxithromycin is run by intramuscular injection. Accordingly, in one embodiment, the dose of roxithromycin is administered orally to a cat. The dose of roxithromycin, administered by injection is often about 5 mg/kg or greater.

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Give your health care provider an inventory of all the medicines, herbs, non-pharmaceuticals, or dietary dietary supplements you use. Side results that you need to report back to your physician or health care professional as soon as attainable: allergic reactions like skin rash or hives, swelling of the face, lips, or tongue anxious bloody or watery diarrhea confusion depressed temper fast, irregular heartbeat fever hallucination, loss of contact with actuality joint, muscle, or tendon pain or swelling lack of memory ache, tingling, numbness in the palms or feet redness, blistering, peeling or loosening of the pores and skin, together with inside the mouth seizures signs and symptoms of aortic dissection such as sudden chest, stomach, or back ache indicators and signs of high blood sugar similar to being extra thirsty or hungry or having to urinate greater than normal. Get helpful, helpful and related well being + wellness data enews Cleveland Clinic is a non-profit tutorial medical heart. Policy Introduction Breast cancer is the most typical reason for most cancers-associated mortality in girls and ~1. Therefore, sure members of these antibiotics exhibit marked cytotoxicity in various mammalian most cancers cell traces (–). However, it should be noted that sure treatments for most cancers may not distinguish between tumor and non-tumor cells in patients and may due to this fact induce undesirable unwanted side effects, similar to genotoxicity (). Ciprofloxacin () is a properly tolerated second-era fluoroquinolone antibiotic used to deal with sufferers with group and hospital-acquired infections (,). Stimulation of the p53 pathway is one of the mechanisms by which anticancer drugs induce the apoptosis of most cancers cells (). Mitochondrial dysfunction mediated by members of the Bcl-2 household, including anti-apoptotic Bcl-2 and pro-apoptotic Bax, is a well known early event of apoptosis (). Studies have demonstrated that ciprofloxacin induces time- and dose-dependent growth inhibition, apoptosis and modulation of the cell cycle in human colorectal (), pancreatic () and human prostate () cancer cell lines. Subsequently, the medium was changed with completely different concentrations of ciprofloxacin (0. Stained cells had been then centrifuged at four hundred × g at room temperature for five min and washed twice with Annexin V binding buffer. Quantitative dedication of p53, Bax and Bcl-2 proteins The expression of p53, Bax and Bcl-2 in cell lysates following therapy with completely different concentrations of ciprofloxacin (0. Statistical analysis For all experiments, a minimum of three separate experiments (n=three) had been performed in triplicate and the outcomes are presented as the imply ± commonplace error of the mean.

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There have been isolated reports of other cardiovascular symptoms corresponding to chest ache, dizziness and palpitations; nonetheless, a causal relationship has not been established. Central nervous system unwanted effects, together with hallucinations, confusion and vertigo, have been reported in occasional patients, however, a cause and impact relationship has not been established. Reporting suspected adverse reactions after registration of medicinal product is necessary. The usual dose is one gram per day administered as 250 mg every six hours or 500 mg each twelve hours. Some clinicians believe that twice every day dosing is inadequate for all however minor infections brought on by extremely vulnerable organisms. Optimum blood levels of erythromycin are achieved when Mayne Pharma Erythromycin capsules are administered in the fasting state, one hour before food. Age, weight and severity of an infection are essential elements in determining dosage for kids. In penicillin allergic sufferers a therapeutic dosage of oral erythromycin should be administered for at least ten days. For continuous prophylaxis in opposition to recurrences of streptococcal infections in persons with a historical past of rheumatic coronary heart illness, the dose is 250 mg twice a day. The grownup dose is 1 gram (20 mg/kg for children) one and one-half to two hours previous to the process and then 500 mg (10 mg/kg for kids) each six hours for eight doses. Allergic reactions accompanying overdosage must be treated by the prompt elimination of unabsorbed drug and supportive measures. What Mayne Pharma Erythromycin Capsules are used for This drugs is an antibiotic used to: deal with infections in several components of the body attributable to micro organism stop infections in patients with a historical past of rheumatic disease who could also be allergic to penicillin. This medication is an antibiotic which belongs to a bunch of medicines called macrolides. Tell your doctor in case you have or have had any of the next medical conditions: irregular or very slow coronary heart beat myasthenia gravis, a situation in which the muscle tissue become weak and tire easily. Some medicines and Mayne Pharma Erythromycin Capsules may interfere with one another. Mayne Pharma Erythromycin Capsules could decrease the effectiveness of some contraception tablets. Your physician could advise you to use an extra method of contraception similar to a barrier method whereas taking Mayne Pharma Erythromycin and for seven days after finishing the course of Mayne Pharma Erythromycin Capsules.

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Zakosh, 35 years: The balloon is then eliminated, leaving the wider sinus to encourage proper drainage. Solution could develop a yellow coloration, but this doesn’t have an effect on the drug’s potency. Results and Discussion In-vitro surveys To evaluate the elements of mechanism of quinolone-induced tendotoxicity, a piece of tendon from a Caucasian affected person was used. Five judges, each with 162 books to read, are figuring out one of the worlds best-recognized literary awards in an unusual 12 months.

Dolok, 24 years: In integrative medicine this emerging area has turn out to be a new dimension in the remedy of resistant intestine infections. Otherwise, these strains could not reach the intestine alive, and subsequently will lack any profit. In every of the therapy groups, there were 5 patients categorized as failing to reply to therapy that were actually related to doctor or father or mother preferences ( desk 2 ). Identifying candidates for Actisite® is a straightforward task to add to the hygienist`s normal screening and treatment routine, and it is recommended that hygienists and dentists discuss in advance specific parameters the dentist would want identified for Actisite® use.

Einar, 51 years: Some imagine that this hyperlink is because of the growth compounds and hormones that the milk incorporates. Vinblastine is a cancer treatment that interferes with the growth and spread of most cancers cells within the body. No dosage adjustment is required for patients with delicate to reasonable hepatic impairment. Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.

Kamak, 57 years: Augmentin (amoxicillin/clavulanic acid) and cephalosporin antibiotics similar to Rocephin (ceftriaxone) or Suprax (cefixime) may also be used. Antibiotics referred to as quinolones Kamagra Oral Jelly (Gel) 100mg - Viagra Generika which work by killing micro organism that cause infections. Vorapaxar: (Moderate) Use warning throughout concurrent use of vorapaxar and nevirapine. Important Information Ofloxacin could cause serious unwanted effects, including tendon issues, nerve damage, serious mood or behavior changes, or low blood sugar.

Giacomo, 30 years: Store all types of this medication at room temperature, shield it from gentle and moisture, and maintain it out of the attain of children. Ivermectin stromectol nbsp 9 Feb 2019 Head lice are actually proof against many over the counter therapies. The individual-time of remark started on the preliminary study visit and ended at either the ultimate study go to or the date of therapy completion; statement intervals by which the child acquired an alternative fluoroquinolone for part of the time (treatment tips modified during the examine period) have been excluded from security analyses. Cimetidine In a pharmacokinetic study investigating the consequences of a single dose of cimetidine, given 2 hours earlier than azithromycin, on the pharmacokinetics of azithromycin, no alteration of azithromycin pharmacokinetics was seen.

Lester, 22 years: Pathogenetic mechanisms in bone marrow suppression for chloramphenicol and thiamphenicol. Terbinafine must be utilized with caution or avoided in sufferers with hypersensitivity reactions, melancholy, gastrointestinal issues, liver failure, and immune suppression secondary to hematologic results. Favouring the foetus radically devalues the pregnant woman, and treats 158 Coercive drugs her like an lifeless incubator, or as a savoir faire medium for the foetus. Since the drug could impair the mental and/or physical skills required for the performance of potentially hazardous tasks, such as working an automobile or equipment, the affected person ought to be cautioned accordingly.

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References

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  • Yoshizawa A, Ota H, Sakaguchi N, et al. Malignant granular cell tumor of the esophagus. Virchows Arch. 2004;444:304-306.
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  • Raghavan, R., F.S. Ashour, and R. Bailey, A review of cutoffs for nutritional biomarkers. Adv. Nutr., 2016.
  • Piper GL, Peitzman AB. Current management of hepatic trauma. Surg Clin North Am. 2010;90: 775-785.
  • Ginsberg JS, Kowalchuk G, Hirsh J, et al: Heparin effect on bone density. Thromb Haemost 1990;64:286-289.
  • Stephens F: Congenital malformations of the rectum, anus and genito-urinary tracts, Baltimore, 1963, Williams & Wilkins. Taghavi K, Sharpe C, Stringer MD: Fetal megacystis: a systematic review, J Pediatr Urol 13:7n15, 2017.